Tuesday, July 9, 2019

Welcome!

Many of you may not be aware that The Coleridge Medical Centre is a member of the South West Clinical Research network  (https://www.nihr.ac.uk/nihr-in-your-area/south-west-peninsula/). In medicine, we are constantly striving to find the most effective treatments for common conditions and research is a key factor that helps to provide this knowledge.  As a practice, we take great care to select studies that we feel will help us treat our patients better.  We feel it is a great opportunity for you as patients to take part in studies that directly benefit you and improve treatment in primary care.  From time to time, you may be invited to take part in one of these studies.  There is no obligation to take part and, if you decline, it will not affect your treatment in any way. 

New research study - GLAD (Genetic Links to Anxiety and Depression)


We are pleased to support a new research study called 'GLAD' (Genetic Links to Anxiety and Depression).  This study is exploring risk factors and genetic links in anxiety and depression.  It aims to better understand depression and anxiety and help find and develop more effective treatments.

The study is open to individuals who:


·         Are aged 16+

·         Live in the UK

·        Are currently experiencing OR have experienced (at any time in their lives) clinical levels of depression and/or anxiety, including bipolar disorder, OCD or related disorders


If you would like to find out more about this research, please visit the study website at:

www.gladstudy.org.uk 

On the study website, you can read further information about the research and you can register to join the study.  In taking part in the research, you would be asked to:

  • provide online consent;
  • complete an online questionnaire (which takes approx 30 minutes); and
  • send a saliva sample through the post - the study team will provide all the necessary sampling equipment and a freepost envelope.

Tuesday, February 26, 2019

New Research Study - 26 February 2019

Are you interested in taking part in a study looking at online support for people who care for a friend or family member affected by psychosis?


The EFFIP Project (E-Support for Families and Friends of Individuals affected by Psychosis) has developed an online resource, called COPe-support (Carers for People with Psychosis e-support resource).  COPe-Support provides peer support, information on psychosis and ways for carers to look after themselves, all online via www.cope-support.org


The study is being run by a team at St George's University of London and they would like to find out if COPe-support works to improve carers' wellbeing and how well they cope with caring.  The research team is inviting carers supporting a loved one affected by psychosis to join the study.  Carers can be parents, partners, siblings, other relatives or close friends.  Participants will be paid £30 in total for their time.


If you are supporting a loved one affected by psychosis, aged 18 or above, living in England, and enjoy using internet resources, the study team would like to tell you more about COPe-support. 


For further information, please contact Dr Jacqueline Sin - Study Coordinator:


Mobile: 07817027035
Email: jasin@sgul.ac.uk
www.cope-support.org

Tuesday, February 5, 2019

New Research Study - 5 February 2019




New Research Study - Type 1 and Type 2 Diabetes

The Practice is supporting a new diabetes project called the ‘Improving Clinical Care in Diabetes (ICCD) Study’.  The project would like to explore why diabetes, and its associated complications, progress quickly in some patients and much slower in others.  Patients who agree to take part would be followed up by a study team based at the Royal Devon & Exeter Hospital for up to 10 years.

Patients are potentially eligible to take part if they:
  • Are age 16 years or above
  • Have a diagnosis of Type 1 or Type 2 Diabetes
  • Are able to given written informed consent to take part and complete study questionnaires
Taking part involves:
  • Signing a consent form (your formal agreement to take part in the research)
  • Sharing information about yourself and your diabetes with the study researchers – by completing some questionnaires and allowing researchers to collect information from your health records
  • Allowing a blood/urine sample leftover from your routine clinical care to be used for the research to include extracting DNA from the sample
Participation in the ICCD Study is entirely voluntary and would not affect the care you receive from your GP or Nurses.  You would be free to withdraw your consent to take part  in the study at any time, without having to give a reason.
If you would like to find out more about this research, please contact our Research Nurse, Chris Wright who will be pleased to discuss the study with you or post you a study information pack (Telephone: 01404 814447).  Chris can also provide support with completing the study paperwork, if this is needed.

Research Update - Spring 2019


Spring 2019
 
New Study Alert!
 
We have started a new study called Improving Clinical Care in Diabetes (ICCD). Please see the blog for more information. Your GP or Nurse may mention the study to you, or you can find information leaflets on our research noticeboard (in the foyer), or ask at Reception for our Research Nurse, Chris Wright to contact you.

Ongoing Studies

 
The Renewed Study has been recruiting well. Please see the blog for more information. Letters for the study were posted out in October 2018 to any patients who were eligible to take part.
 
The Pisces Study is open to young adults (age 18 to 45 years) who are experiencing ongoing back pain.  It involves signing a consent form to allow the study team to collect relevant clinical information from your health records, and completing a short questionnaire about your symptoms.

The Early Arthritis Study is also recruiting well. It is open to adults who have consulted their GP or Nurse Practitioner with joint pain, or adults who have a close relative with a diagnosis of Rheumatoid Arthritis.  It involves attending an appointment at the Practice to sign a consent form, have a blood test and complete a short questionnaire.

 
The TriMaster Study is continuing to recruit patients whose Type 2 Diabetes is poorly controlled.  Your GP or Nurse may mention the study to you if you are eligible to take part, or you may receive information about the study through the post.  All appointments for the study are held at the Royal Devon & Exeter Hospital and participants are asked to take three study medications over the course of a year in addition to their usual diabetes treatments.


Thank you to all patients who have already agreed to take part in these studies.

Our Research Team

 
Dr Nigel De Sousa is our Lead GP for Research and acts as the local Principal Investigator for all of the studies we support.
 
Chris Wright is our Lead Research Nurse.  She organises research at the Practice and is involved in approaching patients about research, and enrolling, consenting and following up patients who agree to take part in our research studies.
 
Pip Hynam - Pip is a Nurse Practitioner who will be consenting and enrolling patients for some of our studies.
 
Dr Alex Werhun - Alex is a salaried GP who will be bringing his research and clinical experience to the research team.
 
Our Research Administrator, Stacy Wilson has now moved on to take up a new post. - we wish her well in her new role.  Administrative support for research is now provided by Mel Conibear, who is one of our Medical Secretaries.

Thank you for all your continued support with research.
 
The Research Team

Sunday, October 21, 2018

Studies we are currently recruiting to:



Studies recruiting in the surgery:



Improving Clinical Care in Diabetes (ICCD)  - This study aims to find out why diabetes, and its associated complications, progress quickly in some patients and much slower in others.  It is open to patients with Type 1 or Type 2 Diabetes.  Participants would be asked to provide information about their diabetes and general health by completing study questionnaires (no more than once a year) and allowing the study researchers to collect information from their health records.  Participants would also be asked to give their consent for a small sample of leftover blood/urine which has been collected for their routine healthcare to be analysed by the hospital laboratory for the study (DNA will be extracted). The study team will follow up participants for up to 10 years.


Renewed - This study is looking at whether a web based care programme can provide patients who have finished primary treatments for breast, colon and prostate cancer with self-management support for a healthy lifestyle and improved mood that will hopefully increase their quality of life and hopefully assist in preventing the recurrence of cancer. Patients will be randomised into 3 groups: Usual care, using "renewed online" for a year, using "Renewed online" plus brief support from a practice nurse. If you are eligible, you will receive a letter from your GP inviting you to take part in the study. This study is being run by the University of Southampton.


Pisces - This study looks at Inflammatory Back Pain in Young Adults.  The study is open to patients aged 18 to 45 who have inflammatory back pain. It will involve answering questions from a clinician. Taking part in the study will not change or alter any of the decisions your doctor will make about your usual care. If you are interested in the study, please speak to a member of staff who will transfer your details to the study team. The study is run by RD+E Heavitree Rheumatology department.




StartRight - This study is open to anyone who has been diagnosed as diabetic in the last year, aged over 18 at diagnosis and is treated by insulin. A simple blood test is taken now and in three years time to help scientists discover whether early testing of blood samples helps to improve diabetes treatment. Appointments are at the RD+E. This study is being organised by The Royal Devon and Exeter NHS foundation trust.


Trimaster - This study is open to type 2 diabetics and will involve patients trying three regularly prescribed diabetes medicines over a year. This is to see which one works best for the patient and to help improve diabetic care for others. If you are eligible you will be asked to provide a simple blood sample. The study is being organised by The Royal Devon and Exeter NHS foundation trust.

Early Arthritis Study The study looks at antibodies in the blood called CCP. This study is open to people aged over 18 with joint or muscle pain. It is also open to first degree relatives over the age of 18 years; of people who have been diagnosed with arthritis. The study involves a simple blood test which will be sent to Leeds Teaching Hospital for further analysis. This study is sponsored by the University of Leeds.





Studies that are self referred:


Exeter 10,000 - This is a study that anybody over the age of 18 who has a permanent address within 25 miles of Exeter can take part in and does not require a referral from your doctor - you can refer yourself. The study aims to recruit over 10,000 people in the area. The project involves a 30 minute appointment - answering some questions about your medical history and lifestyle, and giving a small blood and urine sample. If you let the study team stay in touch with you; they can tell you about the results of their research and may invite you to take part in future studies that require volunteers with your particular characteristics.

Please click the link below to find out more about the study and how to sign up:
http://www.exeter.crf.nihr.ac.uk/extend

Join Dementia Research  - The study is open to anybody over the age of 18 years old. They encourage carers, relatives and the families of people with dementia to register.'Join dementia research' makes it easy for people to register their interest in dementia research, so that they can be contacted about relevant research studies. The goal is to make it possible for anyone and everyone who wants to be involved in dementia research to get the chance to do so.Everybody now has that chance to see what dementia research is taking place, both in their local area and across the nation. The service delivers new opportunities for people to play their part in beating dementia; connecting researchers with people who want to participate in studies.

Please click the link below to find out more about the study and how to sign up:
https://www.joindementiaresearch.nihr.ac.uk/content/about





Studies you may have taken part in that we have recently finished recruiting to:

Daybreak - This study was open to people aged 55 to 85 years old who had experienced a gradual loss of memory over the last 6 months. The study lasted 3 years and involved taking a study medication once a day. The medication will either be a low dose of the study medication, high does of the medication or a placebo. The participant also needed a study partner (close friend, relative) throughout the study.


All Heart  - The study looked at whether adding a medication, Allopurinol, to the regular medication of people with Ischaemic Heart Disease (IHD) could reduce the risk of having a stroke, heart attack or dying due to cardiovascular disease. It was open to patients aged over 60 years with IHD. It involved an appointment with the research nurse in the surgery who took bloods, BP and measurements and then randomised the patient onto the medication. The patient will be on the medication for four years with regular check ups from the study team. If you were eligible, you would have received a letter in the post.

Candid - This study was looking at people who came to the doctor with lung symptoms (for example a cough) or bowel symptoms (for example loose stools). The majority of people who came to the doctor with these symptoms did not have anything wrong with them. However a very few people were at risk of cancer. The aim of the study was to help doctors diagnose cancer quickly so that potential high risk patients are detected sooner and unnecessary examinations are minimised for those patients that are low risk. If you were eligible your doctor would have asked you whether you would have liked to take part.

Alpha This was a study looking for patients with chronic hand eczema that is unresponsive to steroids. The ALPHA study compared two treatments currently used by the NHS:
    1.    A tablet treatment (called Alitretinoin) taken once a day
    2.    A twice weekly treatment called PUVA, where the hands are soaked in a water based liquid (called Meladinine) and then exposed to ultraviolet (UV) light.


If you were eligible to take part you would have received one of the study treatments for 12 to 24 weeks. You would also have been asked to attend RD+E Wonford, Exeter over a one year period. Some of the visits were the same as normal clinic visits and some were additional. During these visits you were asked to complete questionnaires.  You may also have been asked to: have a blood test, take a urine pregnancy test (if applicable), have your hands photographed and have a simple skin sample taken from your hands.

DARE - DARE was an observational study looking to identify genetic and environmental causes of diabetes. The study was for all diabetics. It was also open for non - diabetics. If you were eligible you would have received a letter. The study involved a visit to the practice to see a research nurse who took a simple blood test and asked some questions about your lifestyle.




DASHER The dasher study was looking for eligible patients under the age of 80 who had been recently diagnosed with high blood pressure. The aim of the study was to find the best blood pressure treatment for the individual. The trial involved taking medication already prescribed for high blood pressure; it did not involve testing new drugs. The precipitant was monitored over 18 weeks and had 10 clinic visits that were either near to the individuals home, GP or place of work. Visits to the research centre included: MRI, blood tests, BP monitoring and other vascular measurements.

ATAFUTI This study was open to any women aged between 18 - 70 with a suspected urinary tract infection. The study looked at whether a herb 'Uva Ursi' or an over-the counter treatment could provide relief from symptoms in women with a suspected UTI. They wanted to find out if these medicines could reduce symptoms and therefore reduce the need for antibiotic use. The patient was randomised and received either the herb or the medication. Then were then asked to keep a diary for 2 weeks of their symptoms.


TWICS - The TWICS study was a research study into COPD treatment. People diagnosed with COPD were given a low dose  of theophylline to try and make COPD inhalers work better. The study lasted a year with 3 study visits similar to COPD clinic visits and patients would continue to take their regular medication.  The results of this study have now been published. Please click on the link below to see a summary of the study team's article in The Journal of the American Medical Association

https://jamanetwork.com/journals/jama/article-abstract/2707459 

GARFIELD - This was an observational study looking at people who had been newly diagnosed as suffering with Atrial Fibrillation with a risk factor of stroke.  This was a large study that hoped to recruit people from all around the World.


Please click the link below to the visit the webpage about GARFIELD:

http://af.garfieldregistry.org/


Promaster - This project was for type two diabetic patients and aimed to understand why some people respond better than others to particular diabetes treatments. The study recruited patients who were changing treatment and the study team took blood samples before and after treatment had started. This allowed the team to understand the patients response to the treatment. This could help provide the most effective drugs at the right time to the right people.  

Retromasters Progressors - The progressors study looked into why some people with type 2 diabetes experience more rapid diabetes progression than others. The study involved a visit to the practice to see a research nurse who took a fasting blood sample and urine specimen, take some measurements and ask you some questions about your lifestyle.

DIRECT 3.2 -  This was an observational study looking at individuals who have had different responses to Metformin treatment.  The study hoped to identify characteristics that may have predicted individual response that could help improve the future treatment of diabetes.


FFLUX - This was an observational study looking at a new inhaler:  Flutiform. The trial was open to any patients who used a Seretide Evohaler. At the beginning of the study patients were randomised into one of two groups: Group one continued using their Seretide Evohlaer as normal. Group 2 swapped onto the new Flutiform inhaler. Patients were then asked back use the inhaler given as normal for 12 weeks then invited back into the surgery of analysis. Those patients on Flutiform continued onto part 2 of the study where further tests were taken. The study also reimbursed £25 for each clinic visit. 


MIR  - This study aimed to find out more about whether mirtazapine is helpful for people who are already taking antidepressant medication for depression. If you decided to take part you would have been offered treatment with mirtazapine or a placebo in addition to your usual antidepressant medication.  Questionnaires would have also be completed at various times throughout the study to see how the mirtazapine works.


HEAT - The Heat study was looking at people over the age of 60 who are prescribed aspirin on a regular basis. Taking aspirin is a very valuable in reducing the chance of heart attacks or stroke, but it can increase the chance of getting a stomach ulcer that may, in a few cases, require hospital treatment. Research suggested that stomach ulcers may arise in people who carry a certain bacteria in their stomach: H pylori.  The study involved questions being asked about your medical history, they will also take some simple measurements and then will carry out a simple breath test for H. pylori.  If you were found to have H pylori you would have been given a placebo or treatment.


STOPCUTS - This was an observational study for patients over the age of 65, who were able to take part in normal day to day activities and have used oral steroids for more than a month in the previous 12 months. It was looking at the effectiveness of new socks in skin tear prevention. Patients were randomised into one of two groups: group one wore new protective socks and group two wore normal hosiery. They were visited by a research nurse throughout the 16 week research period and asked to complete a daily diary and questionnaire. At the end of the trial, both groups received the socks.


PMR - This was an observational study for recently diagnosed adult patients with Polymyalgia Rheumatica (PMR).  The study was run in conjunction between Keele Univeristy and Arthritis UK to get a better understanding of the condition, how it is diagnosed and what happens to people who have the condition.  


SNIFS - This was a study looking at people who suffered with recurrent sinusitis.  If you took part, you came to the surgery for an appointment with the nurse and were randomised into one of four groups; one group is treated with normal care (as per their GP), one group will treat themselves with daily steam inhalation, one will treat themselves with daily nasal irrigation with a solution of water, baking soda and salt and the other group will have to do both inhalation and irrigation. 

TASTE - This study was looking to find new ways to treat and prevent sore throats. If you took part, you were treated one of three ways; either by chewing gum, taking a probiotic or treated with usual care.

Hi – Tec - This was an observational study looking into how people with breathing problems use their inhalers. The study was looking to determine how easy it is to use a new inhaler called Pulmojet, compared to two other commonly used inhalers known as Turbohaler and Diskus (Accuhaler).  If you took part you were observed and compared on both inhalers; and given feedback on how to use your own inhaler.

3C - This was an observational study to look at adults with a cough to try to understand which of these people would go on to develop more serious consequences.

TARGET - This was an observational study looking at children with a cough to try to understand which of the children would go on to develop more serious consequences.


Unpacking the Home - This was a study which learnt about the experiences of people who had cared for a family member at the end of their life. Click for link to the study information: http://www.lancs.ac.uk/shm/research/ioelc/programmes/documents/unpacking.pdf

DUTY - This study looked at diagnosing Urinary Tract infections in young children.  Click for link to the study website:
http://www.dutystudy.org.uk/parents.php

PRIBA - This was an observational study looking at Type 2 diabetic patients starting the new diabetic drugs.

DIRECT Progression - This was an observational study looking at how quickly diabetes develops in individual patients.  The study hoped to find a way of testing people when they are newly diagnosed with diabetes to tell us how quickly their diabetes will progress.  This study was taking place all over Europe.


ASCEND - This study looked at heart attacks and stroke in people who have diabetes.