Thursday, September 13, 2018

Welcome!

Many of you may not be aware that The Coleridge Medical Centre is a member of the South West Clinical Research network  (https://www.nihr.ac.uk/nihr-in-your-area/south-west-peninsula/). In medicine we are constantly striving to find the most effective treatments for common conditions and research is a key factor that helps to provide this knowledge.  As a practice we take great care to select studies; which we feel will help us treat our patients better.  We feel it is a great opportunity for you as patients to take part in studies that directly benefit you and improve treatment in primary care.  From time to time you may be invited to take part in one of these studies.  There is no obligation to take part and if you decline it will not affect your treatment in any way. 

Wednesday, September 12, 2018

Studies we are currently recruiting to:



Studies recruiting in the surgery:


Renewed - This study is looking at whether a web based care programme can provide patients who have finished primary treatments for breast, colon and prostate cancer with self-management support for a healthy lifestyle and improved mood that will hopefully increase their quality of life and hopefully assist in preventing the recurrence of cancer. Patients will be randomised into 3 groups: Usual care, using "renewed online" for a year, using "Renewed online" plus brief support from a practice nurse. If you are eligible, you will receive a letter from your GP inviting you to take part in the study. This study is sponsored by the University of Southampton.


Pisces - This study looks at Inflammatory Back Pain in Young Adults.  The study is open to patients aged 18 to 45 who have inflammatory back pain. It will involve answering questions from a clinician. Taking part in the study will not change or alter any of the decisions your doctor will make about your usual care. If you are interested in the study, please speak to a member of staff who will transfer your details to the study team. The study is run by RD+E Heavitree Rheumatology department.



StartRight - This study is open to anyone who has been diagnosed as diabetic in the last year, aged over 18 at diagnosis and is treated by insulin. A simple blood test is taken now and in three years time to help scientists discover whether early testing of blood samples helps to improve diabetes treatment. Appointments are at the RD+E. This study is sponsored by The Royal Devon and Exeter NHS foundation trust.


Trimaster - This study is open to type 2 diabetics and will involve patients trying three regularly prescribed diabetes medicines over a year. This is to see which one works best for the patient and to help improve diabetic care for others. If you are eligible you will be asked to provide a simple blood sample. The study is sponsored by The Royal Devon and Exeter NHS foundation trust.

Early Arthritis Study The study looks at antibodies in the blood called CCP. This study is open to people aged over 18 with joint or muscle pain. It is also open to first degree relatives over the age of 18 years; of people who have been diagnosed with arthritis. The study involves a simple blood test which will be sent to Leeds Teaching Hospital for further analysis. This study is sponsored by the University of Leeds.





Studies that are self referred:


Exeter 10,000 - This is a study that anybody over the age of 18 who has a permanent address within 25 miles of Exeter can take part in and does not require a referral from your doctor - you can refer yourself. The study aims to recruit over 10,000 people in the area. The project involves a 30 minute appointment - answering some questions about your medical history and lifestyle, and giving a small blood and urine sample. If you let the study team stay in touch with you; they can tell you about the results of their research and may invite you to take part in future studies that require volunteers with your particular characteristics.

Please click the link below to find out more about the study and how to sign up:
http://www.exeter.crf.nihr.ac.uk/extend

Join Dementia Research  - The study is open to anybody over the age of 18 years old. They encourage carers, relatives and the families of people with dementia to register.'Join dementia research' makes it easy for people to register their interest in dementia research, so that they can be contacted about relevant research studies. The goal is to make it possible for anyone and everyone who wants to be involved in dementia research to get the chance to do so.Everybody now has that chance to see what dementia research is taking place, both in their local area and across the nation. The service delivers new opportunities for people to play their part in beating dementia; connecting researchers with people who want to participate in studies.

Please click the link below to find out more about the study and how to sign up:
https://www.joindementiaresearch.nihr.ac.uk/content/about




Studies you may have taken part in that we have recently finished recruiting to:

Daybreak - This study was open to people aged 55 to 85 years old who had experienced a gradual loss of memory over the last 6 months. The study lasted 3 years and involved taking a study medication once a day. The medication will either be a low dose of the study medication, high does of the medication or a placebo. The participant also needed a study partner (close friend, relative) throughout the study.



All Heart  - The study looked at whether adding a medication, Allopurinol, to the regular medication of people with Ischamic Heart Disease (IHD) could reduce the risk of having a stroke, heart attack or dying due to cardiovascular disease. It was open to patients aged over 60 years with IHD. It involved an appointment with the research nurse in the surgery who took bloods, BP and measurements and then randomised the patient onto the medication. The patient will be on the medication for four years with regular check ups from the study team. If you wre eligible, you would have received a letter in the post.

Candid - This study was looking at people who came to the doctor with lung symptoms (for example a cough) or bowel symptoms (for example loose stools). The majority of people who came to the doctor with these symptoms did not have anything wrong with them. However a very few people were at risk of cancer. The aim of the study was to help doctors diagnose cancer quickly so that potential high risk patients are detected sooner and unnecessary examinations are minimised for those patients that are low risk. If you wre eligible your doctor would have asked you whether you would have liked to take part.

Alpha This was a study looking for patients with chronic hand eczema that is unresponsive to steroids. The ALPHA study compared two treatments currently used by the NHS:
    1.    A tablet treatment (called Alitretinoin) taken once a day
    2.    A twice weekly treatment called PUVA, where the hands are soaked in a water based liquid (called Meladinine) and then exposed to ultraviolet (UV) light.


If you were eligible to take part you would have received one of the study treatments for 12 to 24 weeks. You would also have been asked to attend RD+E Wonford, Exeter over a one year period. Some of the visits were the same as normal clinic visits and some were additional. During these visits you were asked to complete questionnaires.  You may also have been asked to: have a blood test, take a urine pregnancy test (if applicable), have your hands photographed and have a simple skin sample taken from your hands.

DARE - DARE was an observational study looking to identify genetic and environmental causes of diabetes. The study was for all diabetics. It was also open for non - diabetics. If you were eligible you would have received a letter. The study involved a visit to the practice to see a research nurse who took a simple blood test and asked some questions about your lifestyle.


DASHER The dasher study was looking for eligible patients under the age of 80 who had been recently diagnosed with high blood pressure. The aim of the study was to find the best blood pressure treatment for the individual. The trial involved taking medication already prescribed for high blood pressure; it did not involve testing new drugs. The precipitant was monitored over 18 weeks and had 10 clinic visits that were either near to the individuals home, GP or place of work. Visits to the research centre included: MRI, blood tests, BP monitoring and other vascular measurements.

ATAFUTI This study was open to any women aged between 18 - 70 with a suspected urinary tract infection. The study looked at whether a herb 'Uva Ursi' or an over-the counter treatment could provide relief from symptoms in women with a suspected UTI. They wanted to find out if these medicines could reduce symptoms and therefore reduce the need for antibiotic use. The patient was randomised and received either the herb or the medication. Then were then asked to keep a diary for 2 weeks of their symptoms.

TWICS - The TWICS study was a research study into COPD treatment. People diagnosed with COPD were given a low dose  of theophylline to try and make COPD inhalers work better. The study lasted a year with 3 study visits similar to COPD clinic visits and patients would continue to take their regular medication. 

GARFIELD - This was an observational study looking at people who had been newly diagnosed as suffering with Atrial Fibrillation with a risk factor of stroke.  This was a large study that hoped to recruit people from all around the World.

Please click the link below to the visit the webpage about GARFIELD:

http://af.garfieldregistry.org/

Promaster - This project was for type two diabetic patients and aimed to understand why some people respond better than others to particular diabetes treatments. The study recruited patients who were changing treatment and the study team took blood samples before and after treatment had started. This allowed the team to understand the patients response to the treatment. This could help provide the most effective drugs at the right time to the right people.  


Retromasters Progressors - The progressors study looked into why some people with type 2 diabetes experience more rapid diabetes progression than others. The study involved a visit to the practice to see a research nurse who took a fasting blood sample and urine specimen, take some measurements and ask you some questions about your lifestyle.


DIRECT 3.2 -  This was an observational study looking at individuals who have had different responses to Metformin treatment.  The study hoped to identify characteristics that may have predicted individual response that could help improve the future treatment of diabetes.



FFLUX - This was an observational study looking at a new inhaler:  Flutiform. The trial was open to any patients who used a Seretide Evohaler. At the beginning of the study patients were randomised into one of two groups: Group one continued using their Seretide Evohlaer as normal. Group 2 swapped onto the new Flutiform inhaler. Patients were then asked back use the inhaler given as normal for 12 weeks then invited back into the surgery of analysis. Those patients on Flutiform continued onto part 2 of the study where further tests were taken. The study also reimbursed £25 for each clinic visit. 

MIR  - This study aimed to find out more about whether mirtazapine is helpful for people who are already taking antidepressant medication for depression. If you decided to take part you would have been offered treatment with mirtazapine or a placebo in addition to your usual antidepressant medication.  Questionnaires would have also be completed at various times throughout the study to see how the mirtazapine works.

HEAT - The Heat study was looking at people over the age of 60 who are prescribed aspirin on a regular basis. Taking aspirin is a very valuable in reducing the chance of heart attacks or stroke, but it can increase the chance of getting a stomach ulcer that may, in a few cases, require hospital treatment. Research suggested that stomach ulcers may arise in people who carry a certain bacteria in their stomach: H pylori.  The study involved questions being asked about your medical history, they will also take some simple measurements and then will carry out a simple breath test for H. pylori.  If you were found to have H pylori you would have been given a placebo or treatment.

STOPCUTS - This was an observational study for patients over the age of 65, who were able to take part in normal day to day activities and have used oral steroids for more than a month in the previous 12 months. It was looking at the effectiveness of new socks in skin tear prevention. Patients were randomised into one of two groups: group one wore new protective socks and group two wore normal hosiery. They were visited by a research nurse throughout the 16 week research period and asked to complete a daily diary and questionnaire. At the end of the trial, both groups received the socks.

PMR - This was an observational study for recently diagnosed adult patients with Polymyalgia Rheumatica (PMR).  The study was run in conjunction between Keele Univeristy and Arthritis UK to get a better understanding of the condition, how it is diagnosed and what happens to people who have the condition.  

SNIFS - This was a study looking at people who suffered with recurrent sinusitis.  If you took part, you came to the surgery for an appointment with the nurse and were randomised into one of four groups; one group is treated with normal care (as per their GP), one group will treat themselves with daily steam inhalation, one will treat themselves with daily nasal irrigation with a solution of water, baking soda and salt and the other group will have to do both inhalation and irrigation. 

TASTE - This study was looking to find new ways to treat and prevent sore throats. If you took part, you were treated one of three ways; either by chewing gum, taking a probiotic or treated with usual care.

Hi – Tec - This was an observational study looking into how people with breathing problems use their inhalers. The study was looking to determine how easy it is to use a new inhaler called Pulmojet, compared to two other commonly used inhalers known as Turbohaler and Diskus (Accuhaler).  If you took part you were observed and compared on both inhalers; and given feedback on how to use your own inhaler.


3C - This was an observational study to look at adults with a cough to try to understand which of these people would go on to develop more serious consequences.

TARGET - This was an observational study looking at children with a cough to try to understand which of the children would go on to develop more serious consequences.


Unpacking the Home - This was a study which learnt about the experiences of people who had cared for a family member at the end of their life.

Click for link to the study information: http://www.lancs.ac.uk/shm/research/ioelc/programmes/documents/unpacking.pdf


DUTY - This study looked at diagnosing Urinary Tract infections in young children.

Click for link to the study website:
http://www.dutystudy.org.uk/parents.php


PRIBA - This was an observational study looking at Type 2 diabetic patients starting the new diabetic drugs.


DIRECT Progression - This was an observational study looking at how quickly diabetes develops in individual patients.  The study hoped to find a way of testing people when they are newly diagnosed with diabetes to tell us how quickly their diabetes will progress.  This study was taking place all over Europe.



ASCEND - This study looked at heart attacks and stroke in people who have diabetes.





Tuesday, September 11, 2018

Research Update

Summer 2018... Part2


New Study Alert!
We have started a new study called Renewed. Please see the blog for more information. If you are eligible you will receive a letter in the post.

Ongoing Studies
We started a new study at the beginning of the year - Pisces. Please see the research blog for more information.

The Early Arthritis Study is also recruiting well. Thank-you for all those involved and more information can be found in the foyer at reception or on the blog.

General Details
We have recently sent some feedback forms to patients that have been involved in research. Thank-you to all for your prompt replies.

There will be some new members joining the research team in the next coming months. Please check back for an update soon.

Thank-you for all your continued support with research.

The Research Team.